Lipid Metabolism

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Lipid Metabolism


Lipids

  • triglyceride
  • cholesterol
  • cholesterol esters

Transport

in lipoproteins

#

  • Chylomicrons
    • triglyceride + small amount cholesterol
    • formed in small intestine
    • lipoprotein lipase removes triglyceride
    • remainder of protein taken up by liver
  • Very-low-density lipoprotein
    • formed in liver
    • triglyceride + small quantity of cholesterol
    • when triglyceride removed (by lipoprotein lipase) then becomes intermediate density lipoprotein
  • Intermediate density lipoprotein
    • most taken up by liver
    • further removal of triglyceride to low-density lipoprotein
  • Low-density lipoprotein
    • main carriers of cholesterol
    • Hepatitic LDL receptor binds apoprotein B100
      • → fusing and destruction of LDL
  • High-density lipoprotein
    • produced in liver and intestine
    • nascent contain apoprotein E
    • mature by collecting phospholipids and apoproteins A & C
    • take up cholesterol from cell membranes in peripheral tissues and esterify
    • transports to liver

Enterohepatic circulation

  • some cholesterol converted into bile salts
  • bile salts and cholesterol excreted in bile
  • reabsorbed in terminal ileum
 

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