Paraprotein

Monoclonal immunoglobulin produced by massive clonal expansion of plasma cells

• Can be detected by plasma electrophoresis,

• Light chains (kappa or lambda) leak through kidney into urine - may be found as Bence-Jones protein

Found in

• Multiple Myeloma

• Waldenstrom's macroglobulinaemia

• Plasmacytomas

• Plasma cell leukaemia

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