Medullary Carcinoma of Thyroid

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  • uncommon
  • from thyroid C-cells
  • APUD cell tumour
    • commonly synthesises ands secretes calcitonin (but no clinical effects in otherwise normal individuals)
    • may secrete other products such as serotonin → carcinoid syndrome

Histology

  • sheets of neoplastic cells
  • hyaline stroma
  • amyloid staining pattern

Spread

  • local
  • lymphatic
  • haematogenous

History

Examination

  • lump feels stony hard 
    • due to infiltration of amyloid

Prognosis

  • variable
 

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