Activated partial thromboplastin time

Normal range approximately 28-38 secs

Ingredients

• Kaolin - to activate reaction

• Phospholipid - surface to react on

• Calcium - as factors dependent

• Test plasma

Causes of prolongation

• Indicates deficiency / inhibition of

  • Factor XII
  • factor XI
  • factor IX
  • factor VIII
  • factor X, V, II
  • Fibrinogen
• common causes
  • Haemophilia A
  • Haemophilia B (Christmas disease)
  • Liver Disease
  • Warfarin therapy
  • Heparin therapy
  • Disseminated Intravascular Coagulation

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