Acute Promyelocytic Myeloid Leukaemia

(APML)

• M3 variant of Acute myeloid leukaemia (AML)
• Microscopically
  • Characteristically faggot cells seen (bundles of wood)

• Cytogenetics

  • translocation between chromosomes 15, 17

• translocation occurs at retinoic acid receptor

  • therefore treatment with vitamin A forces differentiation

• Complications

  • increased risk of DIC

    • treatment is of underlying cause so prevent sepsis or obstetric complications

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