Vasoactive Intestinal Peptide
- released by inhibitory myenteric neurons
- released by secretomotor submucosal neurons
- released by vagal fibres to relax pyloric sphincter
- elevates cAMP levels
- released by parasympathetic neurons in salivary gland
- to increase blood flow during secretion
- to produce salivary secretion rich in amylase
- increases secretion of pepsinogen in chief cells
- increase enzyme secretion of pancreatic acinar cell
- may increase duct cell output as well
- contributes to relaxation of submucosal blood vessels to
increase blood flow to intestine
- VIP secreting tumors may lead to watery diarrhoea
14.6.6 VIP = vasoactive Intestinal Peptide
| distribution throughout gut |
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| actions: vasodilation gut; relaxation of sphincters |
VIP in nerves; role in penile erection |
| dysfunction: watery diarrhoea (Verner-Morrison)
syndrome |
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