T Lymphocytes

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T Lymphocytes

• immature lymphocytes mature in thymus
• maturation involves testing for functional MHC and then deletion of self-reactive

T_H

• (helper T cells)
• express CD4
• produce cytokines and active B and T lymphocytes

T_H0

• CD4 positive T-cells from which T_H1 and T_H2 functional classes of T-helper cells are derived
• Secrete IL-2, IL-4, IFN-gamma

T_H1

• Functional subset of CD4 positive T-cell defined by cytokine secretion pattern
• Secrete IFN-gamma 
  • activates macrophages
• Secrete TNF-beta 
  • activates macrophages,
  • inhibits B cells,
  • directly cytotoxic to some T-cells, fibroblasts and tumour cells

T_H2

• Functional subset of CD4 positive T-cell defined by cytokine secretion pattern
• Secrete IL-4 and IL-5
  • activate B cells
• Secrete IL-10
  • inhibits macrophage activation

T_C

• cytotoxic T-cells
• vast majority express CD8
  • small CD4⁺ subset

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