Clomiphene

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Clomiphene


Uses

Mechanism

  • induce GnRH release by occupying oestrogen receptors in the hypothalamus
  • This interferes with feedback mechanisms for FSH and LH release.

Cautions

  • may cause enlargement of cysts
  • multiple ovulations

Route

  • oral

Side-Effects

  • visual disturbance
  • ovarian hyperstimulation
  • hot flushes
  • abdominal discomfort
  • haeadache
  • nausea and vomiting
  • depression
  • insomnia
  • breast tenderness
  • menorrhagia
 

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