Dinoprostone

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Dinoprostone


  • prostaglandin E2 analogue
  • uterus more sensitive to dinoprostone than oxytocin in 2nd trimester

Use

  • induction of labour in 2nd trimester (late therapeutic abortion)
  • induction and augmentation of labour
    • oxytocin preferred due to prostaglandin side effects

Route

  • extra amniotic instillation or 3mg vaginal tablets/pessary / gel (2nd dose 6-8 hours later if necessary)

Adverse Effects

  • diarrhoea
  • flushing
  • headache
  • hypotension
  • fever
  • nausea
  • vomiting

 


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