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Ergometrine


  • produces fast contractions super-imposed on tonic persistent increase in uterine tone
  • Uterus is sensitive at all times, but esp in late pregnancy

Use

  • given with oxytocin to control bleeding due to incomplete abortion
  • with oxytocin as routine management of third stage labour
  • +/- oxytocin for treatment of postpartum haemorrhage

Route

  • 200-500microgramme IM (onset of action 5 mins)
  • in emergency 100-500 microgramme IV reduces onset to 1 min

Cautions

  • cardiac disease
  • hypertension
  • hepatic and renal impairment
  • multiple pregnancy
  • porphyria

Contra-indications

  • induction of labour
  • first and second stages of labour
  • vascular disease
  • severe cardiac disease
  • impaired pulmonary function
  • severe hepatic and renal impairment
  • sepsis
  • severe hypertension
  • eclampsia

Side-effects

  • nausea
  • vomiting
  • headache
  • dizzyness
  • tinnitus
  • abdominal pain
  • chest pain
  • palpitations
  • dyspnoea
  • bradycardia
  • transient hypertension
  • vasoconstriction
  • stroke
  • myocardial infarction
  • pulmonary oedema

Dose

  • 200-500 micrograms
 

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