Fibrates

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Fibrates

Drugs in class

• bezafibrate
• gemfibrozil
• (clofibrate withdrawn due to increased gallstones and ? increased risk gallbladder cancer)

Mechanism of action

• reduce triglyceride concentrations
• stimulate lipoprotein lipase
• enhance LDL uptake in liver
• peroxisome proliferator-activated receptor gamma agonist activity

Side effects

• myositis / rhabdomyolysis
• renal failure exacerbated
• nausea
• abdominal discomfort

Contra-indications

• renal impairment
• hepatic impairment
• gallbladder disease
• pregnancy
• alcoholism

Interactions

• potentiate Anti-coagulants
  • Warfarin
• Bezafibrate increases hypoglycaemic effect of Sulphonylureas
• Increased risk of myositis with Statins

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