Loop Diuretics

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Loop Diuretics

Drugs in class

• frusemide
• bumetanide

Mechanism of Action

• inhibit sodium re-uptake in loop of Henle

Side Effects

• electrolyte disturbances
  • hyponatraemia
  • increased sodium-potassium exchange in distal tubule → Hypokalaemia
  • hypomagnesaemia
  • hypochloraemic Metabolic alkalosis
  • increased calcium excretion
  • Hyperuricaemia / Gout
• Acute Renal Failure
• metabolic
  • carbohydrate intolerance
  • temporary increase in plasma cholesterol / triglyceride concentrations
• ototoxicity
  • tinnitus
  • deafness
• bone marrow depression
  • blood dyscrasias
• hypotension
• GI disturbance
  • nausea
• rashes
• photosensitivity
• pancreatitis

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