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Octreotide
Uses
- acromegalics with persistent raised GH despite surgery/radiotherapy
- in functional neuroendocrine tumours
- to reduce portal pressure in variceal
bleeding
- Treatment in patients with carcinoid syndrome, insulinoma, VIPoma or
glucagonoma
- Treat patients with TSH-secreting tumours
- Effective in acute therapy of bleeding oesophageal varices
Mechanism of action
- synthetic analogue of somatostatin
- which inhibits peptide release from endocrine secreting tumours of the
pituitary or GI tract
Pharmacokinetics
- Metabolized hepatically, some excreted unchanged in the urine
- Plasma t1/2 is 90-120 mins and effects on suppression of
hormone secretion last up to 8 hours
Cautions
- GH secreting tumours can expand causing serious complications
Side effects
- GI disturbances
- Postprandial glucose tolerance may be impaired
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