Spironolactone

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Spironolactone

• Aldosterone antagonist
• potassium-sparing Diuretic

Dose

• 100-400mg (25mg heart failure)
• child 3mg/kg

Uses

• Conns Syndrome
• Heart Failure
• oedema / ascites in Cirrhosis
• malignant ascites
• Nephrotic Syndrome

Contra-indications

• Hyperkalaemia
• Hyponatraemia
• Pregnancy
• Breastfeeding
• Addison's Disease

Side Effects

• gynaecomastia
• GI disturbances
• impotence
• menstrual irregularities
• lethargy
• headache
• confusion
• rash
• Hyperkalaemia
• Hyponatraemia
• hepatotoxic
• osteomalacia
• ? tumour formation over long-term

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