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Thiazolidinediones
- New class of oral drug
- e.g. Rosiglitazone and Pioglitazone
Mechanism
- act on peroxisome proliferator-activated receptor-gamma (PPARg)
gene
- Reduce insulin resistance and blood glucose (requires glucose and lipid
monitoring)
Contraindications:
- cardiac failure
- hepatic impairment
- severe renal insufficiency
Not used in combination with insulin
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