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Korsakoff's syndrome
- poor retention of recent memories
- preserved working memory
- confabulation
- retrograde amnesia
- clear consciousness
- apathy / euphoria
- peripheral neuropathy
- only 20% improve with thiamine
Aetiology
- Thiamine deficiency
- alcoholism
- starvation
- hyperemesis
- (also seen in
- subarachnoid
haemorrhage
- bilateral temporal
lobectomy)
Pathology
- Parenchymal loss
- petechial haemorrhages in walls of 3rd ventricle, mamillary bodies,
thalamus
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