Lewy Body Dementia

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Lewy Body Dementia

Pathology

• Eosinophilic structures (Lewy bodies) in cytoplasm of cortical cells and brain stem
  • Ubiquitin
• Plagues
• Very few neurofibrillary tangles

Clinically

• dementia with fluctuations (not due to delirium)
• Marked visuospatial problems
• Prominent visual hallucinations (50%)
• mild parkinsonism
• marled neuroleptic sensitivity

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