Risk factors for atherosclerosis

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Risk factors for atherosclerosis


(also coronary artery disease, stroke, myocardial infarction, peripheral vascular disease)

  • Age
    • not seen in children
    • often detectable at 20-30
  • Smoking
    • 95% of patients with atherosclerosis are heavy smokers (40% in population at large)
    • Faster progression of atherosclerosis
    • Greater demands on cardiac output as oxygen in blood reduced
  • Hypertension
    • Faster progression of atherosclerosis
    • Renal Damage
    • Increased risk of strokes
    • Ventricular hypertrophy
  • Diabetes mellitus
    • Massively increased progression of atherosclerosis
    • Diabetic ulcers
    • Neuropathy
    • Renal damage
  • Hyperlipidaemia
    • cholesterol
    • triglycerides
  • Family History
    • polymorphism in ACE gene
    • Familial hypercholesterolaemia
  • Sex
    • More common in males and post-menopausal females
  • Increasing age
  • Renal failure
    • Can lead to hypertension
    • Loss of erythropoietin leads to anaemia
  • Hypothyroidism
  • Transplantation
  • Blood coagulation factors
  • fibrinogen
  • C-reactive protein
  • Chlamydia pneumoniae
 

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