Coeliac Disease

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Coeliac Disease


  • immune condition related to ingestion of gluten

Symptoms

  • abdominal discomfort
  • diarrhoea
  • malabsorption

Pathology

  • jejunal biopsy
  • sub-total villous atrophy
  • alpha-gliadin fraction of gluten implicated
  • anti-endomysial antibodies

Diagnosis

  • sub-total villous atrophy
    • disappears on gluten-free diet
    • reappears on introduction of gluten
  • IgA tissue transglutimase antibodies
  • anti-endomysial antibodies

Treatment

  • gluten free diet

Complications

  • increased risk of lymphoma
 

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