Skin

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Skin Immunology
Skin Infections

  • Functions
    • Mechanical Protection
      • keratin
      • thickness
      • melanin against UV
      • micro-organisms
    • Permeability barrier
      • water and electrolytes
      • lipids between epidermal cells
      • keratin
      • (oil soluble substances can enter anyway)
    • Sensory Perception
      • pain
      • touch
      • vibration
      • temperature
    • Thermoregulation
      • Evaporation
      • surface radiation
      • hence capillary loops
    • Immunological barrier
      • keratin as antigen barrier
      • Langerhans cells
      • T lymphocytes
  • Three layers:
  • Appendages
  • Thick Skin:
    • No Hair
    • Thick stratum corneum
    • Deeper dermal papillae and epidermal pegs give improved resistance to abrasion
    • Found on palm, sole of foot
  • Thin Skin
    • Hairy
    • Fairly smooth dermo-epidermal junction
  • dermal papillae
  • epidermal pegs
  •  

     

5.5 SKIN [Hist]

[Currently: 1 lecture + 1 ´ 2h class]

Functions.
Epidermis: cell types; epidermal layers; growth and differentiation (stem cells). Skin appendages: hair, nails. Dermatology: retinoids and epidermal cancers, psoriasis, acne. Teratogenic side effects
Nerve endings of skin; sweat glands (eccrine/merocrine and apocrine).
Blood supply of skin.
 

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