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Urinary Tract Development

Intermediate mesoderm. Endodermal cloaca, urogenital sinus, allantois.
Urogenital ridges, formation of nephridia; mesonephros and its duct.	Pronephros.
Metanephric duct formation from distal end of mesonephric duct.	Double ureter; double kidney
Induction of metanephric tubules which form nephron from glomerulus to connecting tubules. Development of collecting tubules, calyces, ureter from metanephric duct. Upward ‘migration’ of kidneys.	Isolated renal cysts; polycystic kidneys; horseshoe kidneys.
Formation of bladder	Urachal (allantoic) cyst, fistula
Formation of urethra in female and in male	Hypospadias in male; bladder extrophy
Pelvic kidney	Supernumerary renal arteries

devloped from intermediate mesoderm
nephrotomes develop and regress
mesonephroi appear in thoracolumber region - functional if primitive
drained by mesonephric (Wolffian ducts)
uereteric buds appear and induce differentiation of overlying mesonephros to definitive kidney
cloaca partitioned into rectum and urogentital sinus
- urogenital sinus forms bladder, pelvic and penile urethra, vestibule of vagina
kidneys ascend up abominal wall
abnormalities occur when kidney's do not ascend properly, can lead to joining of kidney bases (horseshoe kidney)

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