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Bisphosphonates
Examples
- alendronate
- etidronate
- risedronate
Use
Mechanism
- absorbed onto hydroxyapatite crystals
- reduce rate of growth and dissolution
Contra-indications
- hypocalcaemia
- pregnancy
- breast-feeding
- delayed gastric emptying
Side-Effects
- oesophageal reactions
- oesophagitis
- ulcer
- stricture
- erosions
- abdominal pain
- diarrhoea / constipation
- flatulence
- musculoskeletal pain
- headache
- photosensitivity
- uveitis
- transient decrease in serum phosphate
- nausea
- vomiting
- peptic ulceration
- hypersensitivity
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