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Lipid Metabolism
Lipids
- triglyceride
- cholesterol
- cholesterol esters
Transport
in lipoproteins
#
- Chylomicrons
- triglyceride + small amount cholesterol
- formed in small intestine
- lipoprotein lipase removes triglyceride
- remainder of protein taken up by liver
- Very-low-density lipoprotein
- formed in liver
- triglyceride + small quantity of cholesterol
- when triglyceride removed (by lipoprotein lipase) then becomes
intermediate density lipoprotein
- Intermediate density lipoprotein
- most taken up by liver
- further removal of triglyceride to low-density lipoprotein
- Low-density lipoprotein
- main carriers of cholesterol
- Hepatitic LDL receptor binds apoprotein B100
- → fusing and destruction of LDL
- High-density lipoprotein
- produced in liver and intestine
- nascent contain apoprotein E
- mature by collecting phospholipids and apoproteins A & C
- take up cholesterol from cell membranes in peripheral tissues and
esterify
- transports to liver
Enterohepatic circulation
- some cholesterol converted into bile salts
- bile salts and cholesterol excreted in bile
- reabsorbed in terminal ileum
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