Acute Leukaemias
(Normal WCC 4-11 x 109/l) - in leukaemia can be
raised to 400-500 x 109/l
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defined as >30% blasts in bone marrow
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untreated can be fatal in 6 weeks
-
usually better cure rates than chronic leukaemias
Types
Biology
Clinical Features
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Cytopenias
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anaemia
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neutropenia
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thrombocytopenia
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bleeding
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easy bruising
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purpura
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Neurological signs
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Testicular infiltration
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Hypopyon
Diagnosis
-
clinical features
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Full blood count and blood film
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bone marrow aspirate and trephine
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Immunophenotyping
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Cytogenetic and molecular analysis
Classification
Chromosomal abnormalities
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ALL
-
poor prognosis
-
good prognosis
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AML
-
poor prognosis
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5q deletion
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7q deletion
-
complex
-
good prognosis
Possible causes of leukaemia
Treatment
Prognosis
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