Philadelphia Chromosome
-
Reciprocal translocation of short arm of chromosome 9 onto
chromosome 22
-
resulting (small) chromosome 22 referred to as Philadelphia
chromosome
-
characteristic of Chronic
Myeloid Leukaemia
-
bring BCR region of chromosome 9 next to ABL region of 22.
-
BCR-ABL fusion protein is a constitutively active tyrosine
kinase
-
this drives cell cycle
|