Anencephaly

• neural tube defect

• Failure of proper development of cranium and scalp

• face and base of skull present

• incompatible with life

Clinical features

• usually diagnosed early and termination offered

• polyhydramnios

  • inability to swallow

  • absence of foetal ADH

  • secretions of exposed choroid plexus and meninges

• pregnancy may be prolonged

  • absence of foetal pituitary / oxytocic hormone

• often face presentation

  • may have shoulder dystocia

Prevention

• folic acid pre-conception and in 1st trimester

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