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(Osteoclastoma)
- uncommon
- locally aggressive tumour of bone
- up to 5% of bone neoplasms
- occur at metaphyseo-epihyseal regions of long bones
- ? from undifferentiated mesenchymal cells of connective tissue
framework
- young adults 20-40
- more common in women
Sites
- distal femur
- proximal tibia
- proximal fibula
- distal radius
- proximal humerus
Presentation
- vague swelling at end of long bone
- neighbouring joint inflamed
Investigation
- X-ray
- bone appears cystic with thinned cortex
Histology
- many osteoclastic giant cells present
- thought to be recruited by neoplastic tissue
- can be confused with hyperparathyroidism
Prognosis
- <5% metastasise
- local destruction results in pathological fracture in ~10% of cases
Treatment
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