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- weakening of bone due to problems of bone mineralisation
- often seen with vitamin D deficiency
Causes
- tumour -associated
- examples
- haemangiomas
- non-ossifying bone tumours
- prostate cancer
- neurofibromatosis
- ? due to inhibition of 1a-hydroxylase and
impaired tubular resorption of phosphate
- intestinal malabsorption
- disorders of vitamin D metabolism
- renal disorders
- defective mineralisation
- low activity of alkaline phosphatase
Investigations
- X-ray
- osteopenic
- ?compression fractures of vertebrae
- decrease in bone thickness
- pseudo-fractures
Histology
- exaggeration of osteoid seams
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