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Plague

• Yersinia pestis
• small Gram -ve rods
• Capsule associated with virulence
  • antiphagocytic capsule antigen - F1
• Multiplication in flea

Course

• Flea bite
• 2-6 days incubation
• Tender lymph nodes
• enlargement lymph nodes to buboes with haemorrhagic inflammation
• Halt or dissemination > multisystem failure
  • septicaemia
  • haemorrhagic intravscular coagulation
  • pneumonia
  • meningitis

Prognosis

• Untreated bubonic plague 50% fatality
• Untreated pneumonic plague - 100% fatality

Control

• Streptomycin
• Tetracycline
• Quarantine
• Rodent control
• Isolation
• Chemoprophylaxis
• Vaccination