Sympathetic Nervous system

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Greater Splanchnic Nerve
Least Splanchnic Nerve
Lesser Splanchnic Nerve

Innervates

  • smooth muscle coat of all blood vessels (except interior of brain)
    • Mainly vasoconstrictor
    • Important in maintaining systemic blood pressure and in distribution of blood flow to different vascular beds
  • eccrine sweat glands
  • Pineal gland
  • Heart
  • eye
  • internal organs

Sympathetic ganglia 

  • lie close to central axis of body
  • In 2  sympathetic chains (paravertebral ganglia)
  • unpaired prevertebral ganglia surrounding bases of great arteries
    • coeliac,
    • superior mesenteric
    • inferior mesenteric
  • aortico-renal ganglia (renal  arteries)
  • pelvic ganglia (short adrenergic neurones)
  • chromaffin cells of adrenal medulla (innervated by preganglionic sympathetic neurones)

Preganglionic neurones 

  • lie within 12 thoracic and upper 2-3 lumbar segments of spinal cord
  • in lateral horns of grey matter
  • small (1-4mm) myelinated (B) fibres
  • leave by ventral roots of T1 to L3 and run to sympathetic chain as white rami communicantes
  • fibres run in sympathetic chain and terminate on ganglia there or leave as splanchnic nerves to terminate on prevertebral ganglia and adrenal medulla
  • Thoracic splanchnic nerves (T5-T12) are subpleural

Ganglionic neurones

  • outnunber preganglionic and each preganglionic innervates a number of ganglionic neurons
  • Each ganglionic neurone may recieve input from up to 10 or more preganglionic fibres
  • Vasomotor and sudomotor controlled separately

Postganglionic axons

  •  relatively long, unmyelinated, <1mm in diameter (C fibres)
  • mostly adrenergic
  • exception is eccrine sweat glands which are cholinergic
  • travel in mixed spinal nerves or along blood vessels
 

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