Clindamycin

• Binds 50S subunit
• interferes with binding of amino-acid-acyl-tRNA complex

Activity

• Staphylococci
  • Staphylococcus aureus
  • Staphylococcus epidermidis
• anaerobic gram-negative
• NOT aerobic gram-positive

Resistance

• methylation of 23S ribosomal subunit
• cross-resistance with macrolides