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Bromocriptine
- semi-synthetic ergot derivative
Uses
Mechanism of Action
- D2 receptor agonist
- in anterior pituitary stimulates inhibitory dopamine receptors
- inhibits prolactin secretion
- effects on 5-HT and adrenoceptors
Pharmacokinetics
- administered orally
- 90% absorbed through small intestine
- metabolised in liver
- excreted via bile
- half-life 6-8 hours
Side-Effects
Low dose
- constipation
- nausea
- postural hypotension
High dose
- nasal congestion
- dry mouth
- metallic taste
- cramps in legs
- dystonic reactions
- visual hallucinations
- cardiac arrythmias
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