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Amiodarone

• potassium channel blocker
• prolongs action potential and slows repolarisation
• used in treatment of arrythmias
• causes little or no myocardial depression
• very long half life

Use

• Paroxysmal Supraventricular Tachycardia
• Nodal Tachycardia
• Ventricular Tachycardia
• Cardiac arrest (IV)

Side-Effects

• corneal microdeposits
  • rarely affect vision but may lead to dazzle with night drivers
• phototoxic reactions
• disorders of thyroid function
  • hypothyroidism
  • hyperthyroidism
• Pneumonitis
  • Diffuse Parenchymal Lung Disease
• Peripheral Neuropathy
• Hepatotoxicity
• Optic neuritis
• bradycardia
• conduction disturbances
• persistent slate-grey skin discolouration
• nausea and vomiting
• metallic taste
• tremor
• hot flushes
• sweating
• nightmares
• vertigo
• sleeplessness
• fatigue
• alopecia
• paraesthesia
• benign-raised intracranial pressure
• impotence
• epididymo-orchitis
• ataxia
• rashes
  • exfoliative dermatitis
• hypersensitivity