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Danazol
- anti-gonadotrophin
- reduces GnRH receptors, SHBG leading to increased testosterone and reduced
oestrogen
Mechanism
- inhibits pituitary gonadotrophin secretion
- androgenic activity
- anti-oestrogenic activity
- anti-progestergenic activity
Side Effects
- oligomenorrhoea or amenorrhoea (60%)
- weight gain
- fluid retention
- oily skin / acne (20%)
- deepening voice (10%)
- nausea
- male pattern balding
- cholestatic jaundice
Use
Cautions
- hepatic impairment
- renal impairment
- cardiac impairment
- polycythaemia
Contraindications
- pregnancy
- breast feeding
- thromboembolic disease
- androgen dependent tumours
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