H2 Antagonists

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H2 Antagonists

  • reduce acid secretion in the stomach

Drugs in class

  • ranitidine
  • cimetidine

Adverse Effects

  • GI disturbance
    • diarrhoea
  • altered liver function tests
  • headache
  • dizziness
  • rash
  • tiredness
  • acute pancreatitis
  • bradycardia
  • AV node block
  • confusion
  • depression
  • hallucinations
  • hypersensitivity
  • blood disorders
  • gynaecomastia (cimetidine)

Interactions

  • cimetidine inhibits cytochrome P450 so avoid
    • warfarin
    • phenytoin
    • theophylline
 

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