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Nevirapine
- Routinely used as part of triple combination
Dose
- Orally 200mg once a day for 7-14 days then as 200mg 2x daily (to reduce
s/e)
Mechanism of Action
- Non-competitive inhibitor of HIV reverse transcriptase
- antiviral action synergistic with zidovudine
Adverse Effects
- skin rashes
- hepatitis
- interactions complex
Pharmacokinetics
- well-absorbed orally >90%
- half-life 25-30 hours
- induces cytochrome P450 and increases clearance of OCP
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