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Non Steroidal Anti Inflammatory Drugs
NSAIDs
- reduce inflammation by inhibiting cyclo-oxygenase
- some are supposed to have greater specificity for COX-2 (thus reducing
gastric side-effects)
Drugs in class
- aspirin (non-reversible)
- ibuprofen
- diclofenac
- mefenamic acid
Actions
- analgesia
- reduce temperature
- anti-inflammatory
- respiratory
- GI
- peptic ulceration / gastritis
- renal
- loss of renal autoregulation
- interstitial nephritis (acute oliguria)
- papillary necrosis (long term)
- haem
- reduced platelet adhesiveness
Overdose
- tinnitus
- hyperventilation
- metabolic acidosis
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