Xenical

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Orlistat

• Pancreatic lipase inhibitor

• reduces absorption of dietary fat

NICE guidelines

• BMI >30 or >28 + 2 risk factors

• at least 2.5kg weight loss in preceding month

• 18-75 years

• arrangements for dietary / lifestyles advice

• only >3 months if >5% weight loss

• only >6 months if >10% weight loss

• not usually >1 year treatment, NEVER >2

Side-Effects

•  may produce oily anal leak.

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