Phosphodiesterase Inhibitors

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Phosphodiesterase Inhibitors

Drugs in class

• sildenafil

Use

• Erectile Dysfunction

Mechanism of Action

• increase nitric oxide production
• NO acts as vascular mediator and non-andrenergic non-cholinergic neurotransmitter
• only produces erection with arousal

Contra-indications

• patients on organic nitrates

Adverse Effects

• flushing
• headache

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