Sulphonylureas

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Sulphonylureas

Used 

• Type II Diabetes Mellitus

Mechanism of Action

• Close K⁺(ATP)
  • &rarr depolarization and Ca²⁺ influx
  • &rarr vesicular fusion and secretion and increased insulin synthesis
• Risk of hypoglycaemia directly related to duration of action
  1. Short-acting e.g. Gliclazide, Tolbutamide (2x day)
  2. Long-acting e.g. Glibenclamide (1x day)

Side-effects

• wt gain
•  hypoglycaemia
• GI disturbance
• headache

Contraindications

•  porphyria

Caution

• Breastfeeding
• elderly
• hepatic / renal impairment

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