Theophyllines

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Theophyllines

Example

• aminophylline

Treatment of

• Asthma

  • Acute Asthma Attack

• Chronic Obstructive Airways Disease

Mechanism of Action

• reduce PDE, increase cAMP

• relax smooth muscle

• need levels monitored

Side effects

• CNS

  • nausea

  • fits

• CVS

  • dysrhythmias

  • postural hypotension

Interactions

• cimetidine

  • inhibits metabolism / increases concentration

• ciprofloxacin

  • increased risk of convulsions

• erythromycin

  • increases concentrations

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