Muscle

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  • Can be classified as
  • Muscle development (myogenesis)
    1. Cells in somite commited to becoming myoblasts
    2. these proliferate
    3. mononuclear myoblasts fuse to form multinuclear myotubes, these differentiate into muscle cells and synthesise muscle specific proteins
    4. Maturation as innervation occurs
    • Muscle development controlled by MyoD family of genes
  • Muscle cytoskeleton built from actin and myosin
  • Movement through Sliding filament theory

 

6.8 MUSCLE & INNERVATION [Hist; Neuro; Phys]

Organization of actin and myosin in striated (skeletal and cardiac) and smooth muscle.
Skeletal muscle: gross structure of muscle (myofibre bundles); myofibre structure: sarcolemma, sarcoplasm, sarcoplasmic reticulum, myofibrils, myofilaments, motor end plate, T-tubules. epimysium, perimysium, endomysium
Cardiac muscle as a functional syncytium; contractile signal transmission in the heart.
Smooth muscle structure, innervation and nerve signalling.
Limitations on regeneration and repair following muscle damage.
Histology: functional and metabolic characteristics of different fibre types. Distribution of different fibre types between muscles.
 

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