Histology of Stomach

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  • Stomach
    • mixes food and secretions to chyme
    • rugae allow expansion of stomach as filled
    • gastric pits are openings of gastric glands
    • regions of stomach defined by types of gland present
      • cardiac glands
        • mucus secreting cells help to protect against acid reflux into oesophagus
      • pyloric glands
        • mucous secretion
      • gastric glands
        • produce pepsinogen, HCl, Intrinsic factor (B12 absorption), gastrin and other hormones
        • surface mucous cells secrete thick, adhesive bicarbonate rich mucus
        • composed of neck and base
        • neck composed of mucous neck cells, parietal cells and undifferentiated precursors
        • base contains enteroendocrine cells, chief cells and more parietal cells
        • parietal cells
          • secrete HCl
          • tubulovesicular structure
          • forms canalicular system continuous with apical membrane when stimulated
          • also produce intrinsic factor
        • chief cells secrete pepsinogen
        • enteroendocrine cells secrete gastrin and other hormones
 

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