Thrombocytopenia

• Reduced number of platelets in blood

Increased consumption

• immune mediated

  • idiopathic thrombocytopenic purpura

  • drugs

    • quinines

    •  gold

    • cimetidine

    • penicillin

    • heparin-induced thrombocytopenia

  • infection

    • viruses, e.g. HIV

  • Autoimmune

    • SLE

  • Malignancy

    • lymphoma

• non-immune

  • disseminated intravascular coagulation

  • hypersplenism

  • thrombotic thrombocytopenic purpura

  • haemolytic uraemic syndrome

Decreased production

• aplastic anaemia

• marrow infiltration

  • leukaemia

  • myeloma

  • carcinoma

• megakaryocytic

  • ethanol

  • myelodysplasia

  • HIV

• Nutritional

  • folate

  • vitamin B12

• Drugs

  • chemotherapy

  • chloramphenicol

• Radiation

Other causes of thrombocytopenia

• liver disease

• massive blood transfusion

• extracorporeal circulation

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