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Common variant immunodeficiency
- antibody deficiency
- presents in childhood or adult life (late onset)
- B cell numbers normal, failure to differentiate
- few if any defects in T-cell function
Clinical features
- infections
- follicular hyperplasia of lymph nodes
- splenomegaly
Complications
- May develop autoimmune
disease
- increased risk of lymphoreticular malignancy
Diagnosis
- reduced immunoglobulin
- normal B cells numbers
Treatment
- immunoglobulin replacement
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