Antinuclear Antibodies

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Antinuclear Antibodies

• approx 10% normal individuals at 1/100 dilution

• Useful in diagnosis of

  • systemic lupus erythematosis

    • anti-double-stranded DNA (diagnostic of active SLE)

    • anti-Ro

    • anti-Sm

  • scleroderma

    • anti-centromere

  • Sjogrens syndrome

    • anti-Ro

    • anti-La

  • Inflammatory myositis

  • Discoid lupus

  • Mixed connective tissue disease

  • Autoimmune hepatitis

• can be further classified from Extractable Nuclear Antigens

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