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Extractable Nuclear Antigens

for further characterisation of antinuclear antibodies

ENA	ANA Pattern	Disease association
Ro (SSA)	Fine speckled	Sjogrens (60-80%) SLE (35%) subacute cutaneous lupus scleroderma (10-15%)
La (SSB)	Fine speckled	Sjogrens (50%) SLE (15%)
Smith	Coarse speckled	SLE (15-30%) highly specific
RNP	Coarse speckled	Scleroderma (25%)
Scl-70	Homogenous / intense speckling	MCTD (100%) SLE (40-60%) Scleroderma (25%)
Jo-1	Cytoplasmic speckled	Myositis / lung fibrosis (30%)

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