Thrombosis

[ Home ] [ Up ]

Pages Below:

Thrombosis

• clotting of blood in vein or artery

Virchow's triad

Predisposition to thrombosis when

• there is damage to vessel wall

• change in flow of blood

• change in constituents of blood

E.g.

• Trauma

  • major trauma

  • recent surgery - 7-10days post-op

  • homocysteinuria

• stasis

  • immobility

  • pregnancy

• hypercoagulability (thrombophilia)

  • genetic

    • Factor V Leiden

    • Anti-thrombin III

    • Protein C and S

    • Anti-phospholipid syndrome

  • OCP / oestrogen / HRT

  • polycythaemia

  • antiphospholipid syndrome

  • malignancy

  • smoking

  • nephrotic syndrome

  • obesity

Other Risk Factors

• age

• cardiac failure

• paroxysmal nocturnal haemoglobinuria

• previous history or family history

• sickle cell anaemia

• inflammatory bowel disease

• varicose veins

• recent MI

• obesity

Manifestations

• Deep Venous Thrombosis

• Pulmonary Embolism

Treatment

• aspirin

• anticoagulants

• thrombolysis

[ Home ] [ Up ]