Neutropenia

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Neutropenia

Causes of Neutropenia (Neutrophils <1.5 x 10⁹/l)

• Decreased production

  • general bone marrow failure

  • congenital (e.g. Kostman's syndrome)

  • Cyclical

  • Drug-induced

    • sulphonamides

    • chlorpromazine

    • clozaril

    • diuretics

    • neomercazole

    • gold

• Increased destruction

  • hypersplenism

  • autoimmune

    • + rheumatoid arthritis (Felty's syndrome)

Infections

Extracellular bacteria - Staphylococcal, Gram -ve enteric and systemic fungal infections

• Staphylococcus aureus
• Staph epidermidis
• Escherichia coli
• Klebsiella pneumoniae
• Proteus mirabilis
• Pseudomonas aeruginosa
• Serratia marcescens
• Bacteroides spp.
• Aspergillus fumigatus
• Candida spp. (systemic)
• Mucor spp.

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