Infection in the compromised patient

Neutropenia

Extracellular bacteria - Staphylococcal, Gram -ve enteric and systemic fungal infections

• Staphylococcus aureus
• Staph epidermidis
• Escherichia coli
• Klebsiella pneumoniae
• Proteus mirabilis
• Pseudomonas aeruginosa
• Serratia marcescens
• Bacteroides spp.
• Aspergillus fumigatus
• Candida spp. (systemic)
• Mucor spp.

Opsonin (antibody/complement/splenectomy) deficiency

• Pneumococcus
• Haemophilus influenzae
• Meningococcus
• Streptococcus spp.

Antibody deficiency

As above +

• Campylobacter spp.
• Mycoplasma spp.
• Ureaplasma spp.
• Echovirus

Lytic complement component defects (C5-9)

• Meningococcus
• Gonococcus

Cell mediated immunity

Facultative intracellular pathogens, herpes viruses and polyoma viruses

• Listeria monocytogenes
• Legionella pneumophilia
• Salmonella (non-typhi)
• Nocardia asteroides
• Mycobacterium tuberculae
• Atypical mycobacteria
  • Mycobacterium avium intracellulare
• Candida spp. (mucocutaneous)
• Cryptococcus Neoformans
• Histoplasma capsulatum
• Pneumocystis carinii
• Toxoplasma Gondii
• Herpes Simplex Virus
• Varicella-Zoster Virus / Herpes zoster
• Cytomegalovirus
• Epstein-Barr Virus
• Measles
• Papovirus